Bohr effect: The affinity of Hb for O2 decreases as concentrations of CO2 and/or H+ increase. This typically occurs in peripheral tissues and allows O2 to be supplied more easily to the tissue. Haldane effect: Deoxygenated Hb has a higher affinity for CO2 than oxygenated Hb. Since deoxygenated Hb is typically present in peripheral tissue, uptake of CO2 is facilitated there. CO2 is then transported to the lungs, where it easily dissociates from Hb and is exhaled.
