Do you have to get thyroid lab tests to tell if you have a thyroid problem? Not necessarily. While it's always a good idea to confirm your suspicion with the use of lab tests, there are some very specific signs that indicate your thyroid is off. Signs related to your hair, skin, nails, weight, and more clue you in to the fact that you may have a thyroid problem. You can count up your symptoms to see how many you have to give you an idea of how likely it is you have a thyroid problem.