Non-alcoholic fatty liver disease (NAFLD) is currently the most common liver disease. Non-alcoholic steatohepatitis (NASH) is the advanced form of NAFLD …. While NAFLD is manifested by hepatic steatosis, NASH has the additional features of inflammation, cell injury and ballooning, and mitochondrial changes and/or fibrosis. The understanding of the pathogenesis of NAFLD has been evolving but is still not complete. Fat accumulation in the liver is the first step in the disease process.